4-Methoxybutan-2-amine → 4-[2-[(3-fluorophenyl)amino]-4-pyridinyl]-N-(3-methoxy-1-methylpropyl)-2-pyrimidinamine

HRID 913300Notes

Reaction equation

HRID 913300 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH:5]([NH2:7])[CH3:6].Cl[C:9]1[N:14]=[C:13]([C:15]2[CH:20]=[CH:19][N:18]=[C:17]([NH:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[CH:23]=3)[CH:16]=2)[CH:12]=[CH:11][N:10]=1>>[F:28][C:24]1[CH:23]=[C:22]([NH:21][C:17]2[CH:16]=[C:15]([C:13]3[CH:12]=[CH:11][N:10]=[C:9]([NH:7][CH:5]([CH3:6])[CH2:4][CH2:3][O:2][CH3:1])[N:14]=3)[CH:20]=[CH:19][N:18]=2)[CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 178564404-Methoxybutan-2-amine2×HCID 866467814-(2-chloro-4-pyrimidinyl)-N-(3-fluorophenyl)-2-pyridinamine2×

Product 1

HCID 673897714-[2-[(3-fluorophenyl)amino]-4-pyridinyl]-N-(3-methoxy-1-methylpropyl)-2-pyrimidinamine

Procedure

The title compound was prepared from 3-methoxy-1-methylpropylamine (i.e., the product of Step B) and 4-(2-chloro-4-pyrimidinyl)-N-(3-fluorophenyl)-2-pyridinamine (i.e., the product of Example 17, Step C) in the same fashion as described in Example 17, Step D to give the title compound as a yellow solid, m.p. 104-106° C.

Sources & evidence

ORD record
ord-e16a2b92fb5047a0af3e2fddc7193d0a
Source dataset
uspto-grants-2011_09
Patent number
US08026359B2

Reaction notes

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