反应详情

温度

120 °C

A mixture of 4,6-diiodopyrimidine (1.0 g, 3.01 mmol), 3-fluoroaniline (290 μL, 3.01 mmol), N,N-diisopropylethylamine (782 μL, 4.52 mmol) and n-butanol (3 mL) under nitrogen was stirred at 120° C. for 4 h. After cooling to room temperature, the solution was poured into water and extracted with ethyl acetate. The organic layer was washed once with 1 N hydrochloric acid, followed by brine, dried and concentrated to yield 0.68 g of title compound.

1. temperatureAfter cooling to room temperature
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed once with 1 N hydrochloric acid
4. customdried
5. concentrationconcentrated