反应详情

温度

80 °C

2-Fluoro-5-(trifluoromethyl)benzoic acid (0.016 g, 0.075 mmol) and EDCl (0.015 g, 0.078 mmol) were stirred in DCE (2 mL) for 5 min at rt and then 2-[5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]-N-hydroxyethanimidamide (0.020 g, 0.071 mmol) was added. After 1 h at rt, the reaction was heated to 80° C. for 15 h. Direct purification (SiO2, EtOAc/hexanes) provided the title compound (0.016 g): MS (ESI): m/z 455 (M+1).

1. customDirect purification (SiO2, EtOAc/hexanes)