2,2,2-Trifluoroethyl trifluoromethanesulfonate → 1-(2,2,2-Trifluoroethyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

HRID 913468Notes

Reaction equation

HRID 913468 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[C:11]([C:12]#[N:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][NH:7]2.FC(F)(F)S(O[CH2:22][C:23]([F:26])([F:25])[F:24])(=O)=O>>[F:24][C:23]([F:26])([F:25])[CH2:22][N:7]1[C:8]2[C:4](=[C:3]([C:2]([F:14])([F:1])[F:15])[C:11]([C:12]#[N:13])=[CH:10][CH:9]=2)[CH:5]=[CH:6]1

Participants

3

Reactant 2

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 674054494-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 249844571-(2,2,2-Trifluoroethyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Procedure

Synthesized as described in Example 23 using 4-(trifluoromethyl)-1H-indole-5-carbonitrile and 2,2,2-trifluoroethyl trifluoromethanesulfonate: MS (ES) m/z 293 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-bb0ebbedc144463fa63993f1364d1fbd
Source dataset
uspto-grants-2011_09
Patent number
US08026262B2

Reaction notes

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