Bromomethylcyclopropane → HCID 67404320, compound

HRID 913543Notes

Reaction equation

[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[C:11]([C:14]([F:17])([F:16])[F:15])[C:10]([C:18]#[N:19])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4].Br[CH2:21][CH:22]1[CH2:24][CH2:23]1>>[CH2:1]([C:5]1[N:6]([CH2:21][CH:22]2[CH2:24][CH2:23]2)[C:7]2[C:12]([CH:13]=1)=[C:11]([C:14]([F:16])([F:17])[F:15])[C:10]([C:18]#[N:19])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 67405122HCID 67405122, compound

Product 1

HCID 67404320HCID 67404320, compound

Procedure

Synthesized as described in Example 4 using 2-butyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and (bromomethyl)cyclopropane: 1H NMR (400 MHz, CDCl3) δ 7.48 (s, 2H), 6.57 (s, 1H), 4.05 (d, J=6.3 Hz, 2H), 2.78 (t, J=7.8 Hz, 2H), 1.78 (m, 2H), 1.50 (m, 2H), 1.14 (m, 1H), 1.00 (t, J=7.3 Hz, 3H), 0.60 (m, 2H), 0.35 (m, 2H); MS (ES) m/z 321 (M+1).

Workup

customSynthesized

Sources & evidence

ORD record: ord-1fcfebb2a6b34225916e0047161bf42e
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08026262B2

Reaction notes

Loading…