tert-Butyl bromoacetate → 1,1-Dimethylethyl [4-chloro-5-cyano-2-(trifluoromethyl)-1H-benzimidazol-1-yl]acetate

HRID 913581노트

반응식

HRID 913581 반응식
[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]([F:14])([F:13])[F:12])[NH:7][C:6]=2[CH:5]=[CH:4][C:3]=1[C:15]#[N:16].Br[CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20]>>[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]([F:12])([F:13])[F:14])[N:7]([CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[C:6]=2[CH:5]=[CH:4][C:3]=1[C:15]#[N:16]

참가 물질

3

반응물 2

HCID 79177tert-Butyl bromoacetateHCID 674045324-chloro-2-(trifluoromethyl)-1H-benzimidazole-5-carbonitrile

생성물 1

HCID 690337571,1-Dimethylethyl [4-chloro-5-cyano-2-(trifluoromethyl)-1H-benzimidazol-1-yl]acetate

실험 절차

Synthesized as described in Example 200A from 4-chloro-2-(trifluoromethyl)-1H-benzimidazole-5-carbonitrile and 1,1-dimethylethyl bromoacetate: MS (APCl) m/z 360 (M+1).

후처리

  1. customSynthesized

출처 및 근거

ORD 기록
ord-ecbc34fbde244caeb86c9af1e5553390
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026262B2

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