Dichloromethane → 5-bromo-2-methylsulfanyl-N-(1-methylsulfonylpiperidin-3-yl)pyrimidin-4-amine

HRID 91359Notes

Reaction equation

[Br:1][c:2]1[c:3]([NH:10][CH:11]2[CH2:12][NH:13][CH2:14][CH2:15][CH2:16]2)[n:4][c:5]([S:8][CH3:9])[n:6][cH:7]1.[CH3:26][S:27]([Cl:28])(=[O:29])=[O:30].[CH:17]([N:18]([CH:19]([CH3:20])[CH3:21])[CH2:22][CH3:23])([CH3:24])[CH3:25].[Cl:31][CH2:32][Cl:33]>>[Br:1][c:2]1[c:3]([NH:10][CH:11]2[CH2:12][N:13]([S:27]([CH3:26])(=[O:29])=[O:30])[CH2:14][CH2:15][CH2:16]2)[n:4][c:5]([S:8][CH3:9])[n:6][cH:7]1

Participants

Reactant 4

HCID 6344Dichloromethane

HCID 31297Methanesulfonyl chloride

HCID 81531Diisopropylethylamine

HCID 698100765-bromo-2-methylsulfanyl-N-piperidin-3-ylpyrimidin-4-amine

Product 1

HCID 698117045-bromo-2-methylsulfanyl-N-(1-methylsulfonylpiperidin-3-yl)pyrimidin-4-amine

Sources & evidence

ORD record: ord-c89b3091ba244ffe89e42d360fddf131
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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