2-Chloroethyl methyl ether → 2-Methyl-1-[2-(methyloxy)ethyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile

HRID 913738Notes

Reaction equation

HRID 913738 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([C:11]([F:14])([F:13])[F:12])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=2.[CH3:17][O:18][CH2:19][CH2:20]Cl>>[CH3:1][C:2]1[N:3]([CH2:20][CH2:19][O:18][CH3:17])[C:4]2[C:9]([CH:10]=1)=[C:8]([C:11]([F:12])([F:14])[F:13])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=2

Participants

3

Reactant 2

HCID 123162-Chloroethyl methyl etherHCID 533093462-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 674052772-Methyl-1-[2-(methyloxy)ethyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Procedure

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 2-chloroethyl methyl ether: MS (ES) m/z 283 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-830d9c849fb44ddba555451dbaa3c642
Source dataset
uspto-grants-2011_09
Patent number
US08026262B2

Reaction notes

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