HCID 59318557, compound → HCID 131729200, compound

HRID 913779Notes

Reaction equation

HRID 913779 reaction equation
[Na+].[O:2]([CH2:9][C:10]([O:12][CH2:13][C:14]([F:20])([F:19])[S:15]([O-:18])(=[O:17])=[O:16])=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Na].FC(F)(F)S([O-])(=O)=O.[C:30]1([CH:36]([SH+:43][C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[C:37]1([CH:36]([SH+:43][C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1.[F:20][C:14]([F:19])([S:15]([OH:18])(=[O:17])=[O:16])[CH2:13][O:12][C:10](=[O:11])[CH2:9][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 59318557HCID 59318557, compoundHCID 131729198HCID 131729198, compound

Product 1

HCID 131729200HCID 131729200, compoundYield 92.5%

Procedure

<2> The reaction described in <3> of Synthesis Example 1 was performed under the same conditions, except that the phenoxyacetyloxymethyl difluoromethanesulfonic acid sodium salt (3.66 g) produced in <1> of Synthesis Example 5 above was used instead of the benzoyloxymethyldifluorosulfonic acid sodium salt in the reaction with diphenylmethylphenylsulfonium trifluoromethanesulfonic acid sodium salt, and thus 4.35 g (yield 92.5%) of phenoxyacetic acid 2,2-difluoro-2-sulfoethyl ester diphenylmethylphenylsulfonium salt as shown in the following reaction scheme 11 was obtained. The structure of the product was confirmed by 1H-NMR (see FIG. 10).

Workup

  1. custom<2> The reaction described in <3> of Synthesis Example 1
  2. customproduced in <1> of Synthesis Example 5

Sources & evidence

ORD record
ord-b461cfe54bea486e83a28b9961208960
Source dataset
uspto-grants-2011_09
Patent number
US08026390B2

Reaction notes

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