4-Amino-1-methylpiperidine → HCID 25252910, compound

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The title compound was synthesized from 4-(9-cyclopentyl-7-ethyl-7-fluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and. 1-methylpiperidin-4-amine. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.89 (t, J=7.3 Hz, 3H) 1.60-1.75 (m, 11H) 1.84-2.09 (m, 5H) 2.19 (s, 3H) 2.80 (d, J=11.1 Hz, 2H) 3.26 (s, 3H) 3.60-3.83 (m, 3H) 3.94 (s, 3H) 4.78 (t, J=8.1 Hz, 1H) 7.35-7.60 (m, 2H) 7.80 (s, 1H) 8.08 (d, J=7.6 Hz, 1H) 8.16 (s, 1H) 8.32 (d, J=8.3 Hz, 1H). Melting point: 149-153° C. [M+H] calc'd for C29H40FN7O3, 554. found 554.

Provenance & Evidence