Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → HCID 25252912, compound

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Reaction Steps

The title compound was synthesized from 4-(9-cyclopentyl-7-ethyl-7-fluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and 1-methylazetidin-3-amine hydrochloride. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.89 (t, J=7.3 Hz, 3H) 1.6-1.87 (m, 7H) 1.89-1.99 (m, 3H) 2.29 (s, 3H) 3.04 (t, J=7.1 Hz, 2H) 3.27 (s, 3H) 3.59 (t, J=7.2 Hz, 2H) 3.64-3.87 (m, 2H) 3.95 (s, 3H) 4.29-4.53 (m, 1H) 4.79 (t, J=8.1 Hz, 1H) 7.42-7.59 (m, 2H) 7.82 (s, 1H) 8.17 (s, 1H) 8.34 (d, J=8.3 Hz, 1H) 8.61 (d, J=6.8 Hz, 1H). [M+H] calc'd for C27H36FN7O3, 526. found 526.

Provenance & Evidence