HRID914178
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
The title compound was synthesized from 4-(9-cyclohexyl-7-fluoro-7-vinyl-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and 1-amino 4-methylpiperazine. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.48-2.05 (m, 8H) 2.22 (br. s., 3H) 2.42 (m, 4H) 2.93 (t, J=4.55 Hz, 4H) 3.28 (br. s., 3H) 3.72 (m, 2H) 3.93 (br. s., 3H) 4.87 (m, 1H) 5.39 (d, 2H) 5.99 (m, 1H) 7.43 (br. s, 2H) 7.82 (s, 1H) 8.12 (br. s., 1H) 8.32 (d, J=8.0 Hz, 1H) 9.36 (s, 1H). Melting point: 253-263° C. [M+H] calculated for C28H37FN8O3, 553. found 553.
WORKUP
后处理
- customas described in the General procedure for amide bond synthesis