反应详情

2-Methyl-2-{[4-(3-phthalimidopropyl)-1,3-thiazol-2-yl]thio}propionic acid tert-butyl ester (31.1 g) obtained in Example 32 was dissolved in ethanol (400 mL), hydrazine monohydrate (10 mL) was added, and the mixture was refluxed for 2 hr. The precipitated solid was removed by filtration, and the filtrate was concentrated under reduced pressure. Water and dichloromethane were added to the residue, and the organic layer was washed with water, and dried over magnesium sulfate. The solvent was concentrated under reduced pressure to give the title compound (20.1 g). The obtained compound was used in the next reaction without purification.

1. temperaturethe mixture was refluxed for 2 hr
2. customThe precipitated solid was removed by filtration
3. concentrationthe filtrate was concentrated under reduced pressure
4. additionWater and dichloromethane were added to the residue
5. washthe organic layer was washed with water
6. dry with materialdried over magnesium sulfate
7. concentrationThe solvent was concentrated under reduced pressure