p-Trifluoromethylphenylboric acid → 2-Methyl-2-({4-[2-({5-[4-(trifluoromethyl)phenyl]pyridin-2-yl}oxy)ethyl]-1,3-thiazol-2-yl}thio)propionic acid hydrochloride

HRID 914321Notes

Reaction equation

HRID 914321 reaction equation
C([O:5][C:6](=[O:26])[C:7]([S:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][CH2:17][O:18][C:19]2[CH:24]=[CH:23][C:22](Br)=[CH:21][N:20]=2)[N:15]=1)([CH3:9])[CH3:8])(C)(C)C.[F:27][C:28]([F:40])([F:39])[C:29]1[CH:34]=[CH:33][C:32](OB(O)O)=[CH:31][CH:30]=1.[ClH:41].C(OCC)(=O)C>>[ClH:41].[CH3:9][C:7]([S:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][CH2:17][O:18][C:19]2[CH:24]=[CH:23][C:22]([C:32]3[CH:33]=[CH:34][C:29]([C:28]([F:40])([F:39])[F:27])=[CH:30][CH:31]=3)=[CH:21][N:20]=2)[N:15]=1)([CH3:8])[C:6]([OH:5])=[O:26]

Participants

4

Reactant 3

HCID 17793420p-Trifluoromethylphenylboric acidHCID 21866389Hydrogen chloride-ethyl acetateHCID 597591722-[(4-{2-[(5-Bromopyridin-2-yl)oxy]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester

Product 1

HCID 673976292-Methyl-2-({4-[2-({5-[4-(trifluoromethyl)phenyl]pyridin-2-yl}oxy)ethyl]-1,3-thiazol-2-yl}thio)propionic acid hydrochloride

Procedure

A compound obtained using 2-[(4-{2-[(5-bromopyridin-2-yl)oxy]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester synthesized in Example 100-1 and 4-(trifluoromethyl)phenylboric acid as starting materials by operations similar to those of Example 100-2 and Example 100-3 was reacted with 4 mol/L hydrochloric acid-ethyl acetate to give the title compound.

Workup

  1. customA compound obtained

Sources & evidence

ORD record
ord-194f9a510f9648ea93f930fbc94f2e31
Source dataset
uspto-grants-2011_09
Patent number
US08026370B2

Reaction notes

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