p-Trifluoromethylphenylboric acid → 2-Methyl-2-({4-[2-({5-[4-(trifluoromethyl)phenyl]pyridin-2-yl}oxy)ethyl]-1,3-thiazol-2-yl}thio)propionic acid hydrochloride

Participants

Reaction Steps

A compound obtained using 2-[(4-{2-[(5-bromopyridin-2-yl)oxy]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester synthesized in Example 100-1 and 4-(trifluoromethyl)phenylboric acid as starting materials by operations similar to those of Example 100-2 and Example 100-3 was reacted with 4 mol/L hydrochloric acid-ethyl acetate to give the title compound.

Provenance & Evidence