反应详情

温度

130 °C

N,N-Diisopropylethylamine (13.1 g) was added to 2-{[4-(2-Aminoethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid tert-butyl ester (27.9 g) synthesized in Example 7 and 2-chloro-5-ethylpyrimidine (13.2 g), and the mixture was stirred at 130° C. for 20 hr. The reaction mixture was directly purified by silica gel chromatography (elution solvent; hexane:ethyl acetate=2:1 to 1:1) to give the title compound (23.5 g) as a slightly yellow solid.

1. customThe reaction mixture was directly purified by silica gel chromatography (elution solvent; hexane:ethyl acetate=2:1 to 1:1)