2-Chloro-4-cyanopyridine → HCID 67398777, compound

HRID 914441Notes

Reaction equation

HRID 914441 reaction equation
C([O:5][C:6](=[O:26])[C:7]([S:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][CH2:17][NH:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[N:15]=1)([CH3:9])[CH3:8])(C)(C)C.[Cl:27][C:28]1[CH:29]=[C:30]([CH:33]=[CH:34][N:35]=1)[C:31]#[N:32].Cl.C(OCC)(=O)C>C(OCC)C>[ClH:27].[C:31]([C:30]1[CH:33]=[CH:34][N:35]=[C:28]([N:18]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH2:17][CH2:16][C:14]2[N:15]=[C:11]([S:10][C:7]([CH3:8])([CH3:9])[C:6]([OH:5])=[O:26])[S:12][CH:13]=2)[CH:29]=1)#[N:32]

Participants

5

Reactant 3

HCID 5686382-Chloro-4-cyanopyridineHCID 21866389Hydrogen chloride-ethyl acetateHCID 597593122-({4-[2-(Heptylamino)ethyl]-1,3-thiazol-2-yl}thio)-2-methylpropionic acid tert-butyl ester

Product 1

HCID 67398777HCID 67398777, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A compound obtained using 2-({4-[2-(heptylamino)ethyl]-1,3-thiazol-2-yl}thio)-2-methylpropionic acid tert-butyl ester synthesized in Example 303-2 and 2-chloroisonicotinonitrile as starting materials and by operations similar to those of Example 303-3 and Example 303-4 was dissolved in diethyl ether, and reacted with 4 mol/L hydrochloric acid-ethyl acetate to give the title compound.

Workup

  1. customA compound obtained

Sources & evidence

ORD record
ord-688f6e522b9e4a4da3d762c12b80a556
Source dataset
uspto-grants-2011_09
Patent number
US08026370B2

Reaction notes

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