反应详情

2-(Ethoxymethylene)-2-cyanoacetic acid ethyl ester (78.2 g) and phenylhydrazine (50.0 g) were dissolved in ethanol (500 mL), and the mixture was refluxed for 3 hr. After cooling, the reaction mixture was concentrated under reduced pressure. Hexane (500 mL) was added, to the residue, and the residue was washed by suspending and filtered. The obtained solid was vacuum dried to give the title compound (86.0 g) as a white solid.

1. temperaturethe mixture was refluxed for 3 hr
2. temperatureAfter cooling
3. concentrationthe reaction mixture was concentrated under reduced pressure
4. additionHexane (500 mL) was added, to the residue
5. washthe residue was washed
6. filtrationfiltered
7. customdried