反应详情

温度

65 °C

3-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester (64.8 g) synthesized in Reference Example 15 was dissolved in tetrahydrofuran (500 mL), isoamyl nitrite (98.5 g) was added, and the mixture was stirred at 65° C. for 3 hr. After cooling, the reaction mixture was concentrated under reduced pressure. Hexane (500 mL) was added to the residue, and the residue was washed by suspending and filtered. The obtained solid was vacuum dried to give the title compound (43.0 g) as a white solid.

1. temperatureAfter cooling
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. additionHexane (500 mL) was added to the residue
4. washthe residue was washed
5. filtrationfiltered
6. customdried