N-Methylaniline → HCID 67400592, compound

HRID 914507Notes

Reaction equation

[C:1]([CH2:4][C:5]1[N:6]=[C:7]([S:10][C:11]([CH3:16])([CH3:15])[C:12]([OH:14])=[O:13])[S:8][CH:9]=1)([OH:3])=O.[CH3:17][NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH3:15][C:11]([S:10][C:7]1[S:8][CH:9]=[C:5]([CH2:4][C:1]([N:18]([CH3:17])[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:3])[N:6]=1)([CH3:16])[C:12]([OH:14])=[O:13]

Participants

Reactant 2

HCID 7515N-Methylaniline

HCID 67399201HCID 67399201, compound

Product 1

HCID 67400592HCID 67400592, compound

Procedure

The title yellow resin (2.0 g) was obtained using 2-{[4-(carboxymethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid resin synthesized in Example 461-4 and N-methylaniline (0.52 ml) as starting materials and by an operation similar to that of Example 461-5.

Sources & evidence

ORD record: ord-b371b82c597a40ecbb2eba551294eddf
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08026370B2

Reaction notes

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