Aniline → HCID 67396451, compound

HRID 914509Notes

Reaction equation

HRID 914509 reaction equation
[C:1]([CH2:4][C:5]1[N:6]=[C:7]([S:10][C:11]([CH3:16])([CH3:15])[C:12]([OH:14])=[O:13])[S:8][CH:9]=1)([OH:3])=O.[NH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.FC(F)(F)C(O)=O>>[NH:17]([C:1](=[O:3])[CH2:4][C:5]1[N:6]=[C:7]([S:10][C:11]([CH3:16])([CH3:15])[C:12]([OH:14])=[O:13])[S:8][CH:9]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 3

HCID 6115AnilineHCID 6422Trifluoroacetic acidHCID 67399201HCID 67399201, compound

Product 1

HCID 67396451HCID 67396451, compound

Procedure

The title yellow resin (2.9 g) was obtained using 2-{[4-(carboxymethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid resin synthesized in Example 461-4 and aniline as starting materials and by an operation similar to that of Example 461-5. A part of the resin was cleaved with trifluoroacetic acid and the structure was confirmed.

Sources & evidence

ORD record
ord-8c47f95f531147c380abb2891dcb90bf
Source dataset
uspto-grants-2011_09
Patent number
US08026370B2

Reaction notes

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