Trifluoroacetic acid → HCID 15140306, compound

HRID 914654Notes

Reaction equation

HRID 914654 reaction equation
C([O:5][C:6]([CH2:8][CH2:9][CH:10]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:6]([CH2:8][CH2:9][CH:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:16]([O:18][CH2:19][CH3:20])=[O:17])([OH:7])=[O:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 15186642HCID 15186642, compound

Product 1

HCID 15140306HCID 15140306, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of compound 10 (19.6 g, 68.05 mmol), in 400 mL CH2Cl2 is added 400 mL of TFA. The mixture is stirred under during 48 h at room temperature. The reaction mixture is concentrated under vacuum, coevaporated two times with cyclohexane to eliminate excess TFA yielded 15.8 g compound 11 as oil used without further purification.

Workup

  1. concentrationThe reaction mixture is concentrated under vacuum

Sources & evidence

ORD record
ord-cf899c680f6a4e669b4653cf29017c7a
Source dataset
uspto-grants-2007_09
Patent number
US07264956B2

Reaction notes

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