5-Bromo-2-nitropyridine → HCID 16748110, compound

HRID 914736Notes

Reaction equation

HRID 914736 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([N+:8]([O-:10])=[O:9])=[N:6][CH:7]=1.[C@H:11]12[CH2:17][C@H:14]([NH:15][CH2:16]1)[CH2:13][N:12]2[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19]>>[N+:8]([C:5]1[N:6]=[CH:7][C:2]([N:15]2[CH2:16][C@@H:11]3[CH2:17][C@H:14]2[CH2:13][N:12]3[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=[CH:3][CH:4]=1)([O-:10])=[O:9]

Participants

3

Reactant 2

HCID 8176205-Bromo-2-nitropyridineHCID 11521263(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

Product 1

HCID 16748110HCID 16748110, compound

Procedure

5-Bromo-2-nitropyridine, prepared as described in (J. Am. Chem. Soc., (1945) 67, 668), and tert-butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate, prepared as described in (J. Med. Chem., (1988) 31, 1598-1611), were coupled according to the procedure of Example 2A to provide the title compound.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-965b885d41d540a4bdcf38ea63716d96
Source dataset
uspto-grants-2007_09
Patent number
US07265115B2

Reaction notes

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