HCID 16748110, compound → HCID 16748232, compound

HRID 914752Notes

Reaction equation

HRID 914752 reaction equation
[N+:1]([C:4]1[N:9]=[CH:8][C:7]([N:10]2[CH2:15][C@@H:14]3[CH2:16][C@H:11]2[CH2:12][N:13]3C(OC(C)(C)C)=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].FC(F)(F)C(O)=O.C(Cl)Cl>>[N+:1]([C:4]1[N:9]=[CH:8][C:7]([N:10]2[CH2:15][C@@H:14]3[CH2:16][C@H:11]2[CH2:12][NH:13]3)=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 16748110HCID 16748110, compoundHCID 21863450Trifluoroacetic acid methylene chloride

Product 1

HCID 16748232HCID 16748232, compound

Procedure

The product from Example 3A was treated with trifluoroacetic acid:methylene chloride (1:2) at ambient temperature for 2 hours. The volatiles were removed under reduced pressure, and the residue was purified on SiO2 (5% MeOH/CH2Cl2/1%NH4OH) to provide the title compound as a yellow gum. MS (DCI/NH3) m/z 221 (M+H)+, 238 (M+NH4)+.

Workup

  1. customThe volatiles were removed under reduced pressure
  2. customthe residue was purified on SiO2 (5% MeOH/CH2Cl2/1%NH4OH)

Sources & evidence

ORD record
ord-fd3a509e277a44b599c2ab36b577bde3
Source dataset
uspto-grants-2007_09
Patent number
US07265115B2

Reaction notes

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