5-Bromo-3-methylisothiazole → HCID 16749564, compound

HRID 914760Notes

Reaction equation

HRID 914760 reaction equation
[C@H:1]12[CH2:7][C@H:4]([NH:5][CH2:6]1)[CH2:3][N:2]2[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].Br[C:16]1[S:20][N:19]=[C:18]([CH3:21])[CH:17]=1>>[CH3:21][C:18]1[CH:17]=[C:16]([N:5]2[CH2:6][C@@H:1]3[CH2:7][C@H:4]2[CH2:3][N:2]3[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[S:20][N:19]=1

Participants

3

Reactant 2

HCID 6009595-Bromo-3-methylisothiazoleHCID 11521263(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

Product 1

HCID 16749564HCID 16749564, compound

Procedure

tert-Butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate, prepared as described in (J. Med. Chem., (1988) 31, 1598-1611) and 5-bromo-3-methylisothiazole, prepared as described in (U.S. Pat. No. 3,840,665) were coupled according to the procedure described in Example 1A to provide the title compound.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-2d1383404e2f4778b49750d6e47da59f
Source dataset
uspto-grants-2007_09
Patent number
US07265115B2

Reaction notes

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