3,7-Diazabicyclo(3.3.1)nonane → 3-(6-Chloro-3-pyridinyl)-3,7-diazabicyclo[3.3.1]nonane

HRID 914763노트

반응식

HRID 914763 반응식
[CH:1]12[CH2:9][CH:5]([CH2:6][NH:7][CH2:8]1)[CH2:4][NH:3][CH2:2]2.[Cl:10][C:11]1[CH:16]=[CH:15][C:14](I)=[CH:13][N:12]=1>>[Cl:10][C:11]1[N:12]=[CH:13][C:14]([N:3]2[CH2:4][CH:5]3[CH2:9][CH:1]([CH2:8][NH:7][CH2:6]3)[CH2:2]2)=[CH:15][CH:16]=1

참가 물질

3

반응물 2

HCID 1927203,7-Diazabicyclo(3.3.1)nonaneHCID 43971762-Chloro-5-iodopyridine

생성물 1

HCID 99647193-(6-Chloro-3-pyridinyl)-3,7-diazabicyclo[3.3.1]nonane수율 10%

실험 절차

3,7-Diazabicyclo[3.3.1]nonane, prepared as described in (Garrison, G. L. et. al., J. Org. Chem. 58, 27, (1993) 7670), and 2-chloro-5-iodopyridine were processed as described in Example 57A. The crude was purified by flash chromatography (silica gel; CHCl3:MeOH:NH4OH; 90:5:1) to provide the title compound (10% yield). MS (DCI/NH3) m/z 238 (M+H)+.

후처리

  1. customThe crude was purified by flash chromatography (silica gel; CHCl3:MeOH:NH4OH; 90:5:1)

출처 및 근거

ORD 기록
ord-5a3b2178dc734c6f8e9581a7aa401c41
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07265115B2

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