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3,7-Diazabicyclo(3.3.1)nonane → 3-(6-Chloro-3-pyridinyl)-3,7-diazabicyclo[3.3.1]nonane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,7-Diazabicyclo(3.3.1)nonane | HCID 192720 | — |
| 反応物 | 2-Chloro-5-iodopyridine | HCID 4397176 | — |
| 生成物 | 3-(6-Chloro-3-pyridinyl)-3,7-diazabicyclo[3.3.1]nonane | HCID 9964719 | 10% |
反応手順
3,7-Diazabicyclo[3.3.1]nonane, prepared as described in (Garrison, G. L. et. al., J. Org. Chem. 58, 27, (1993) 7670), and 2-chloro-5-iodopyridine were processed as described in Example 57A. The crude was purified by flash chromatography (silica gel; CHCl3:MeOH:NH4OH; 90:5:1) to provide the title compound (10% yield). MS (DCI/NH3) m/z 238 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07265115B2 |
| 出典データセット | uspto-grants-2007_09 |
| ORD ID | ord-5a3b2178dc734c6f8e9581a7aa401c41 |
| 出典メモ | uspto-grants-2007_09 |