Hydrochloric Acid → HCID 69142424, compound

HRID 914769Notes

Reaction equation

HRID 914769 reaction equation
[CH3:1][O:2][C:3]1[CH:30]=[CH:29][C:6]([C:7]([NH:9][C@@H:10]([C:14]([N:16]2[CH2:21][CH2:20][CH:19]([CH:22]3[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]3)[CH2:18][CH2:17]2)=[O:15])[CH:11]([CH3:13])[CH3:12])=[O:8])=[CH:5][CH:4]=1.[ClH:31].CCOCC>C(Cl)Cl>[ClH:31].[CH3:1][O:2][C:3]1[CH:30]=[CH:29][C:6]([C:7]([NH:9][C@@H:10]([C:14]([N:16]2[CH2:17][CH2:18][CH:19]([CH:22]3[CH2:23][CH2:24][N:25]([CH3:28])[CH2:26][CH2:27]3)[CH2:20][CH2:21]2)=[O:15])[CH:11]([CH3:13])[CH3:12])=[O:8])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 10273336HCID 10273336, compound

Product 1

HCID 69142424HCID 69142424, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1-(4-methoxybenzoyl-D-valinyl)-4-(1-methylpiperidin-4-yl)piperidine (14.75 g, 35.5 mmol) in anhydrous CH2Cl2 (400 mL) cooled to 0° C. is added HCl in Et2O (1 M, 35.9 mL, 35.9 mmol). After approximately 5 min, the solvent is removed in vacuo to give 16.9 g (quantitative) of the title compound as a white foam.

Workup

  1. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-d633c74d2dac404f83bf85ea7c9f65a3
Source dataset
uspto-grants-2007_09
Patent number
US07265121B2

Reaction notes

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