Hydrochloric Acid → HCID 69416536, compound

HRID 914771Notes

Reaction equation

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]([NH:12][C@@H:13]([C:17]([N:19]3[CH2:24][CH2:23][CH:22]([CH:25]4[CH2:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]4)[CH2:21][CH2:20]3)=[O:18])[CH:14]([CH3:16])[CH3:15])=[O:11])[CH:8]=2)[CH:3]=[CH:2]1.[ClH:32]>>[ClH:32].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]([NH:12][C@@H:13]([C:17]([N:19]3[CH2:24][CH2:23][CH:22]([CH:25]4[CH2:26][CH2:27][N:28]([CH3:31])[CH2:29][CH2:30]4)[CH2:21][CH2:20]3)=[O:18])[CH:14]([CH3:15])[CH3:16])=[O:11])[CH:8]=2)[CH:3]=[CH:2]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 10180725HCID 10180725, compound

Product 1

HCID 69416536HCID 69416536, compoundYield 98.3%

Procedure

1-(Indole-6-carbonyl-D-valinyl)-4-(1-methylpiperidin-4-yl)piperidine (3.4 g, 8.03 mmol) is suspended in 0.2 N aqueous HCl (40.2 mL, 8.03 mmol) and sonicated. The resulting solution is lyophilized to give 3.64 g (98%) of the title compound.

Workup

customsonicated

Sources & evidence

ORD record: ord-d1dac21182cc45fcbc0bc515847e75d9
Source dataset: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07265121B2

Reaction notes

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