反应详情

After dissolving 1.30 g of 1-(1-benzylpiperidin-4-yl)-2-[2-(trifluoromethyl)phenyl]ethanone in 10 ml of 1,2-dichloroethane, 0.58 ml of 1-chloroethyl chloroformate was added while stirring at room temperature and the mixture was heated to reflux for 1 hour. The solvent was distilled off under reduced pressure, 10 ml of methanol was added to the residue and heating to reflux was continued for 30 minutes. The solvent was distilled off under reduced pressure, ethyl acetate/n-hexane was added to the residue and the precipitate was filtered out to obtain the title compound (916 mg, 83% yield).

1. additionwas added
2. temperaturethe mixture was heated
3. temperatureto reflux for 1 hour
4. distillationThe solvent was distilled off under reduced pressure, 10 ml of methanol
5. additionwas added to the residue
6. temperatureheating
7. temperatureto reflux
8. distillationThe solvent was distilled off under reduced pressure, ethyl acetate/n-hexane
9. additionwas added to the residue
10. filtrationthe precipitate was filtered out