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HRID914897

反应详情

EQUATION

反应方程式

HRID 914897 的结构方程式

REACTANTS

反应物

2
结构：CCOC(C)=O.Cl
HCID21866389

未命名化合物

结构：CC(C)(C)OC(=O)N1CCC(O)(C#Cc2ccccc2F)CC1
HCID22248203

未命名化合物

PRODUCTS

生成物

1
结构：Cl.OC1(C#Cc2ccccc2F)CCNCC1
HCID22248440

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

After dissolving 1.4 g of 1-(tert-butoxycarbonyl)-4-hydroxy-4-[(2-fluorophenyl)ethynyl]piperidine in 20 ml of ethyl acetate, 10 ml of 4N hydrogen chloride/ethyl acetate was added and the mixture was stirred overnight at room temperature. The solvent was distilled off under reduced pressure to obtain 1.28 g of 4-hydroxy-4-[(2-fluorophenyl)ethynyl]piperidine hydrochloride.

WORKUP

后处理

  1. additionwas added
  2. distillationThe solvent was distilled off under reduced pressure