反应详情

温度

85 °C

To a solution of 44 mg (0.15 mmol) 7-Bromo-2-methyl-4-pyrrolidin-1-yl-quinazoline in 1.2 ml dioxane/dimethoxyethane 1:1 was added 57 mg (0.375 mmol) 4-methoxy-phenyl-boronic acid in 0.4 ml ethanol, 7 mg (0.007 mmol) Dichloro[1,1′-Bis(diphenylphosphino)-ferrocene]-palladium (II) dichloromethan adduct, and 0.6 ml 2 M Na2CO3aq. and the mixture was heated to 85° C. for 12 h. After filtration, the mixture was purified by reversed phase column chromatography eluting with an acetonitrile/water (formic acid) gradient yielding 17 mg (35%) of the title compound. MS m/e (%): 320.4 (M+H+, 100).

1. filtrationAfter filtration
2. customthe mixture was purified by reversed phase column chromatography
3. washeluting with an acetonitrile/water (formic acid) gradient