HCID 17639086, compound → 3-amino-N-[2-(dimethylamino)ethyl]benzenesulfonamide

HRID 914960Notes

Reaction equation

HRID 914960 reaction equation
[CH3:1][N:2]([CH3:18])[CH2:3][CH2:4][NH:5][S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-])=O)[CH:10]=1)(=[O:8])=[O:7]>C(O)C.CC(O)=O.[Pd]>[NH2:15][C:11]1[CH:10]=[C:9]([S:6]([NH:5][CH2:4][CH2:3][N:2]([CH3:18])[CH3:1])(=[O:8])=[O:7])[CH:14]=[CH:13][CH:12]=1

Participants

5

Reactant 1

HCID 17639086HCID 17639086, compound

Product 1

HCID 167906463-amino-N-[2-(dimethylamino)ethyl]benzenesulfonamideYield 99.7%

Reagents, catalysts & solvents 3

HCID 176Acetic AcidCatalystHCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 3 (0.8 g) in ethanol (10 mL) was subjected to catalytic hydrogenation (10% Pd/C, Degussa, 0.8 g, 3 drops of AcOH, 1 atm.) overnight. To work up, the solids were filtered the filtrate was dried under vacuum to afford 4 as a solid (0.71 g) which was used in the next step without further purification.

Workup

  1. filtrationthe solids were filtered the filtrate
  2. customwas dried under vacuum

Sources & evidence

ORD record
ord-1a6e05943ec14adda9c6cee38578a3db
Source dataset
uspto-grants-2007_09
Patent number
US07265122B2

Reaction notes

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