HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → tert-Butyl (3-(2-dimethylamino-ethoxy)-4-methyl-phenyl)-carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N,N-Dimethylaminoethyl chloride hydrochloride | HCID 11636816 | — |
| Reactant | tert-butyl N-(3-hydroxy-4-methylphenyl)carbamate | HCID 44668374 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | tert-Butyl (3-(2-dimethylamino-ethoxy)-4-methyl-phenyl)-carbamate | HCID 71166994 | — |
Reaction Steps
A mixture of 7 (2.16 g, 9.68 mmol), 2-(dimethylamino)-ethyl chloride hydrochloride (1.53 g, 10.6 mmol) and K2CO3 (5.35 g, 3.87 mmol) in DME (28 mL)/H2O (7 mL) was heated under reflux overnight. After cooling to room temperature, the solution was diluted with EtOAc (100 mL) and the resulting solution was washed with H2O (2×100 mL) and brine (100 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07265122B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-1a8e4aa02f014da6aafcb36c5f97e6cb |
| Source note | uspto-grants-2007_09 |