反应详情

温度

90 °C

To a solution of 21 (250 mg, 0.67 mmol) in DMF (5 mL) were sequentially added sodium carbonate (149 mg, 1.41 mmol). and 22 (183 mg, 0.808 mmol). The reaction was placed under a N2 atmosphere and heated at 90° C. for 16 hours. After cooling to room temperature, the reaction mixture was extracted with ethyl acetate and washed with water and brine. The ethyl acetate extracts were dried over anhydrous magnesium sulfate and evaporated. The residue was purified via reversed phase HPLC to yield the title compound as a pale yellow solid (20 mg, 6%).

1. temperatureAfter cooling to room temperature
2. extractionthe reaction mixture was extracted with ethyl acetate
3. washwashed with water and brine
4. dry with materialThe ethyl acetate extracts were dried over anhydrous magnesium sulfate
5. customevaporated
6. customThe residue was purified via reversed phase HPLC