Hydrazine → HCID 27055575, compound

HRID 914987Notes

Reaction equation

HRID 914987 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[CH2:11][C:12]([O:14]CC)=O.[NH2:17][NH2:18]>C(O)C>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[CH2:11][C:12]([NH:17][NH2:18])=[O:14]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 2839036Ethyl (3,4-dihydro-1H-isoquinolin-2-yl)acetate

Product 1

HCID 27055575HCID 27055575, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 90 (2.0 g, 9.12 mmol) and hydrazine (5.1 g, 91 mmol) in ethanol (30 mL) was heated at reflux overnight. The mixture was concentrated under reduced pressure to give 91 (1.87 g ˜100%) which was used without further purification.

Workup

  1. temperatureat reflux overnight
  2. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-62c165ed74a74b769d7b88b2dc611239
Source dataset
uspto-grants-2007_09
Patent number
US07265122B2

Reaction notes

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