反应详情

温度

70 °C

A mixture of 102 (1.0 g, 3.2 mmol), 4-benzylpiperidine (103) (0.62 g, 3.5 mmol), and potassium carbonate (1.1 g, 8.0 mmol) in acetonitrile (10 ml) was heated at 70° C. overnight. It was allowed to cool to room temperature and partitioned between EtOAc (150 mL) and water (150 mL). The organic layer was washed with water (100 ml), brine (100 ml), dried over MgSO4, and concentrated. The residue was chromatographed on silica gel (8:1 to 4:1 to 2:1 hexanes/EtOAc) to give 104 (0.26 g, 21%).

1. temperatureto cool to room temperature
2. custompartitioned between EtOAc (150 mL) and water (150 mL)
3. washThe organic layer was washed with water (100 ml), brine (100 ml)
4. dry with materialdried over MgSO4
5. concentrationconcentrated
6. customThe residue was chromatographed on silica gel (8:1 to 4:1 to 2:1 hexanes/EtOAc)