HCID 69331890, compound → HCID 69331496, compound

HRID 915046Notes

Reaction equation

HRID 915046 reaction equation
[CH2:1]([N:3]1[C:8](=[O:9])[CH:7]=[CH:6][C:5]([C:10]2[N:15]=[C:14](C(O)=O)[C:13]([NH:19][CH2:20][C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)=[N:12][C:11]=2[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[N:4]1)[CH3:2]>ClC1C=CC=CC=1Cl>[CH2:1]([N:3]1[C:8](=[O:9])[CH:7]=[CH:6][C:5]([C:10]2[C:11]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[N:12][C:13]([NH:19][CH2:20][C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)=[CH:14][N:15]=2)=[N:4]1)[CH3:2]

Participants

3

Reactant 1

HCID 69331890HCID 69331890, compound

Product 1

HCID 69331496HCID 69331496, compoundYield 84.9%

Reagents, catalysts & solvents 1

HCID 72391,2-DichlorobenzeneSolvent

Procedure

A mixture of 6-(1-ethyl-6-oxo-1,6-dihydro-3-pyridazinyl)-3-[(4-methoxybenzyl)amino]-5-phenyl-2-pyrazinecarboxylic acid (1.02 g) in 1,2-dichlorobenzene (20 ml) was refluxed for 3 hours. The mixture was purified by column chromatography on silica gel eluting with a mixture of n-hexane and EtOAc (40:60 v/v) to give 2-ethyl-6-{5-[(4-methoxybenzyl)amino]-3-phenyl-2-pyrazinyl}-3(2H)-pyridazinone as a solid (783 mg).

Workup

  1. temperaturewas refluxed for 3 hours
  2. customThe mixture was purified by column chromatography on silica gel eluting with a mixture of n-hexane and EtOAc (40:60 v/v)

Sources & evidence

ORD record
ord-7953ffc80eeb43e4bb4491535660ce62
Source dataset
uspto-grants-2007_09
Patent number
US07265120B2

Reaction notes

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