Hydrochloric Acid → HCID 69333212, compound

Participants

Reaction Steps

A solution of 6-[5-amino-6-(methylsulfonyl)-3-phenyl-2-pyrazinyl]-2-isopropyl-3(2H)-pyridazinone (200 mg) in a mixture of 1N aq. NaOH (1 ml) and dioxane (2 ml) was refluxed for 6 hours. After cooling, the mixture was adjusted to pH 4 with 1N HCl to give a precipitate. The precipitate was collected by filtration and crystallized from DMSO and water to give 6-(5-amino-6-oxo-3-phenyl-1,6-dihydro-2-pyrazinyl)-2-isopropyl-3(2H)-pyridazinone (123 mg).

Provenance & Evidence