Hydrochloric Acid → HCID 69333212, compound

HRID 915048Notes

Reaction equation

HRID 915048 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:5]([C:12]2[CH:13]=[CH:14][C:15](=[O:21])[N:16]([CH:18]([CH3:20])[CH3:19])[N:17]=2)=[N:6][C:7]=1S(C)(=O)=O.Cl.[OH-:29].[Na+]>O1CCOCC1>[NH2:1][C:2]1[C:7](=[O:29])[NH:6][C:5]([C:12]2[CH:13]=[CH:14][C:15](=[O:21])[N:16]([CH:18]([CH3:20])[CH3:19])[N:17]=2)=[C:4]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69331470HCID 69331470, compound

Product 1

HCID 69333212HCID 69333212, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 6-[5-amino-6-(methylsulfonyl)-3-phenyl-2-pyrazinyl]-2-isopropyl-3(2H)-pyridazinone (200 mg) in a mixture of 1N aq. NaOH (1 ml) and dioxane (2 ml) was refluxed for 6 hours. After cooling, the mixture was adjusted to pH 4 with 1N HCl to give a precipitate. The precipitate was collected by filtration and crystallized from DMSO and water to give 6-(5-amino-6-oxo-3-phenyl-1,6-dihydro-2-pyrazinyl)-2-isopropyl-3(2H)-pyridazinone (123 mg).

Workup

  1. temperaturewas refluxed for 6 hours
  2. temperatureAfter cooling
  3. customto give a precipitate
  4. filtrationThe precipitate was collected by filtration
  5. customcrystallized from DMSO and water

Sources & evidence

ORD record
ord-7f120c70ca234e9c8ced214459993a47
Source dataset
uspto-grants-2007_09
Patent number
US07265120B2

Reaction notes

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