HCID 9633626, compound → HCID 58958434, compound

HRID 915168Notes

Reaction equation

HRID 915168 reaction equation
[CH3:1][N:2](/[CH:4]=[N:5]/[C:6]1[S:7][C:8]([C:11]([O:13]C(C)(C)C)=[O:12])=[CH:9][N:10]=1)[CH3:3].Cl.O1CCOCC1>>[CH3:3][N:2](/[CH:4]=[N:5]/[C:6]1[S:7][C:8]([C:11]([OH:13])=[O:12])=[CH:9][N:10]=1)[CH3:1]

Participants

3

Reactant 2

HCID 9633626HCID 9633626, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 58958434HCID 58958434, compound

Conditions

Temperature
75 °C

Procedure

To tert-butyl 2-{[(1E)-(dimethylamino)methylidene]amino}-1,3-thiazole-5-carboxylate 23-1 (12.3 g, 48.17 mmol) was added 35 mL of 4N HCl/dioxane. This suspension was warmed to 75° C. under nitrogen for 18 hours. The solid was filtered off, washed with dioxane and ethyl ether, and then dried under high vacuum at 45° C. 1H-NMR (DMSO): 8.57 ppm (s, 1H); 8.07 ppm (s, 1H); 3.26 ppm (s, 3H); 3.12 ppm (s, 3H).

Workup

  1. filtrationThe solid was filtered off
  2. washwashed with dioxane and ethyl ether
  3. customdried under high vacuum at 45° C

Sources & evidence

ORD record
ord-1667f49c47f5446cb6be6414a6c73c3d
Source dataset
uspto-grants-2007_09
Patent number
US07265134B2

Reaction notes

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