HCID 9633626, compound → HCID 58958434, compound

Participants

Reaction Conditions

Reaction Steps

To tert-butyl 2-{[(1E)-(dimethylamino)methylidene]amino}-1,3-thiazole-5-carboxylate 23-1 (12.3 g, 48.17 mmol) was added 35 mL of 4N HCl/dioxane. This suspension was warmed to 75° C. under nitrogen for 18 hours. The solid was filtered off, washed with dioxane and ethyl ether, and then dried under high vacuum at 45° C. 1H-NMR (DMSO): 8.57 ppm (s, 1H); 8.07 ppm (s, 1H); 3.26 ppm (s, 3H); 3.12 ppm (s, 3H).

Provenance & Evidence