Potassium Iodide → HCID 69280242, compound

HRID 915391Notes

Reaction equation

HRID 915391 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([OH:15])[CH:13]=2)[CH:8]=[CH:7]1)[CH3:2].Cl[CH2:18][C:19]1[N:23]([CH3:24])[N:22]=[C:21]([C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=2)[C:20]=1[CH3:32].C(=O)([O-])[O-].[Cs+].[Cs+].[I-].[K+]>CC(C)=O>[CH2:1]([O:3][C:4](=[O:16])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH2:18][C:19]3[N:23]([CH3:24])[N:22]=[C:21]([C:25]4[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=4)[C:20]=3[CH3:32])[CH:13]=2)[CH:8]=[CH:7]1)[CH3:2]

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 10796Cesium carbonateHCID 68821422(6-Hydroxy-indol-1-yl)-acetic acid ethyl esterHCID 69280234HCID 69280234, compound

Product 1

HCID 69280242HCID 69280242, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

In analogy to the procedure described for example 1 e], (6-hydroxy-indol-1-yl)-acetic acid ethyl ester was reacted with 5-chloromethyl-3-(4-chloro-phenyl)-1,4-dimethyl-1H-pyrazole in the presence of cesium carbonate and potassium iodide in acetone to give {6-[5-(4-chloro-phenyl)-2,4-dimethyl-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester as yellow crystals.

Sources & evidence

ORD record
ord-527ea52061564a5d8683ad2fd67d3a0d
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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