Lithium Hydroxide → HCID 69283042, compound

HRID 915392Notes

Reaction equation

C([O:3][C:4](=[O:31])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH2:16][C:17]3[N:18]([CH3:30])[N:19]=[C:20]([C:23]4[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=4)[C:21]=3[CH3:22])[CH:13]=2)[CH:8]=[CH:7]1)C.[Li+].[OH-]>>[Cl:29][C:26]1[CH:27]=[CH:28][C:23]([C:20]2[C:21]([CH3:22])=[C:17]([CH2:16][O:15][C:12]3[CH:13]=[C:14]4[C:9]([CH:8]=[CH:7][N:6]4[CH2:5][C:4]([OH:31])=[O:3])=[CH:10][CH:11]=3)[N:18]([CH3:30])[N:19]=2)=[CH:24][CH:25]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69280242HCID 69280242, compound

Product 1

HCID 69283042HCID 69283042, compound

Procedure

In analogy to the procedure described for example 1 f], {6-[5-(4-chloro-phenyl)-2,4-dimethyl-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester was treated with LiOH to obtain {6-[5-(4-chloro-phenyl)-2,4-dimethyl-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid as colorless crystals.

Sources & evidence

ORD record: ord-47f4b63d67b649278667d526f9f6eb9a
Source dataset: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07265149B2

Reaction notes

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