Lithium Hydroxide → HCID 69282575, compound

HRID 915401Notes

Reaction equation

HRID 915401 reaction equation
C([O:5][C:6](=[O:34])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:18][C:19]3[N:20]([CH3:33])[N:21]=[C:22]([C:26]4[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=4)[C:23]=3[CH2:24][CH3:25])[CH:15]=2)[CH:10]=[CH:9]1)(C)(C)C.[Li+].[OH-]>>[Cl:32][C:29]1[CH:30]=[CH:31][C:26]([C:22]2[C:23]([CH2:24][CH3:25])=[C:19]([CH2:18][O:17][C:14]3[CH:15]=[C:16]4[C:11]([CH:10]=[CH:9][N:8]4[CH2:7][C:6]([OH:34])=[O:5])=[CH:12][CH:13]=3)[N:20]([CH3:33])[N:21]=2)=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 69284502HCID 69284502, compound

Product 1

HCID 69282575HCID 69282575, compound

Procedure

In analogy to the procedure described for example 1 f], {6-[5-(4-chloro-phenyl)-4-ethyl-2-methyl-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester was treated with LiOH to obtain {6-[5-(4-chloro-phenyl)-4-ethyl-2-methyl-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid as brown crystals.

Sources & evidence

ORD record
ord-8e4ce5039f57489db6e2666b9523ce45
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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