Lithium Hydroxide → {5-[5-(4-chloro-phenyl)-1-methyl-1H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid

HRID 915408Notes

Reaction equation

HRID 915408 reaction equation
C([O:5][C:6](=[O:32])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH2:18][C:19]3[CH:23]=[C:22]([C:24]4[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=4)[N:21]([CH3:31])[N:20]=3)=[CH:14][CH:15]=2)[CH:10]=[CH:9]1)(C)(C)C.[Li+].[OH-]>>[Cl:30][C:27]1[CH:28]=[CH:29][C:24]([C:22]2[N:21]([CH3:31])[N:20]=[C:19]([CH2:18][O:17][C:13]3[CH:12]=[C:11]4[C:16](=[CH:15][CH:14]=3)[N:8]([CH2:7][C:6]([OH:32])=[O:5])[CH:9]=[CH:10]4)[CH:23]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 69283050{5-[5-(4-chloro-phenyl)-1-methyl-1H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester

Product 1

HCID 69283039{5-[5-(4-chloro-phenyl)-1-methyl-1H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid

Procedure

In analogy to the procedure described for example 1 f], {5-[5-(4-chloro-phenyl)-1-methyl-1H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester was treated with LiOH to obtain {5-[5-(4-chloro-phenyl)-1-methyl-1H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid as colorless solid.

Sources & evidence

ORD record
ord-ed025a4b66fc42e3bf6d1a8a180eee17
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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