Iodoethane → 2-ethyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester

HRID 915409Notes

Reaction equation

HRID 915409 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[NH:8][N:7]=1)=[O:5])[CH3:2].[CH2:21](I)[CH3:22].[OH-].[K+]>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH2:21][CH3:22])[N:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:19])([F:20])[F:18])=[CH:13][CH:12]=2)[CH:10]=1)=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 6340IodoethaneHCID 14797Potassium HydroxideHCID 178468625HCID 178468625, compound

Product 1

HCID 667778182-ethyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester

Procedure

In analogy to the procedure described for example 2 a], 5-(4-trifluoromethyl-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (PCT Int. Appl. (2003), WO 2004000785 A2) was reacted with ethyl iodide in the presence of potassium hydroxide to to give 2-ethyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester as colorless crystals.

Sources & evidence

ORD record
ord-6ecfd8dde30f44febddbb8cdbab2693a
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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