HRID915411

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4278

N,N,N′,N′-Tetramethylazodicarboxamide

C6H12N4O2

HCID13831

Tributylphosphine

C12H27P

HCID69280245

未命名化合物

HCID69283069

tert-Butyl (6-hydroxy-1H-indol-1-yl)acetate

C14H17NO3

PRODUCTS

生成物

结构：CCn1nc(-c2ccc(C(F)(F)F)cc2)cc1COc1ccc2ccn(CC(=O)OC(C)(C)C)c2c1

HCID69284503

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described for example 3 c], (6-hydroxy-indol-1-yl)-acetic acid tert-butyl ester (example 1 d]) was reacted with [2-ethyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-methanol in the presence of N,N,N′,N′-tetramethyl azodicarboxamide and tributylphosphine to give {6-[2-ethyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester as colorless oil.

WORKUP

后处理

customexample 1 d

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-865896c807ba438a86956ddeea494f67
来源数据集: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07265149B2
来源说明: uspto-grants-2007_09

反应 SMILES

[C:1]([O:5][C:6](=[O:18])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=2)[CH:10]=[CH:9]1)([CH3:4])([CH3:3])[CH3:2].[CH2:19]([N:21]1[C:25]([CH2:26]O)=[CH:24][C:23]([C:28]2[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][CH:29]=2)=[N:22]1)[CH3:20].CN(C)C(N=NC(N(C)C)=O)=O.C(P(CCCC)CCCC)CCC>>[C:1]([O:5][C:6](=[O:18])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:26][C:25]3[N:21]([CH2:19][CH3:20])[N:22]=[C:23]([C:28]4[CH:29]=[CH:30][C:31]([C:34]([F:36])([F:35])[F:37])=[CH:32][CH:33]=4)[CH:24]=3)[CH:15]=2)[CH:10]=[CH:9]1)([CH3:4])([CH3:2])[CH3:3]