反应详情

温度

85 °C

A mixture of [2-methyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-acetonitrile (267 mg, 1 mmol), sodium hydroxide (403 mg, 10 mmol), water (4 ml) and ethanol (4 ml) was stirred vigorously at 85° C. for 14 h. The reaction mixture was poured onto crushed ice and aqueous HCl and extracted three times with ethyl acetate. The combined extracts were washed with water and brine, and dried over anhydrous sodium sulfate. Evaporation of the solvent under reduced pressure gave 286 mg (1 mmol, quant.) of the title compound as off-white crystals.

1. additionThe reaction mixture was poured
2. extractionextracted three times with ethyl acetate
3. washThe combined extracts were washed with water and brine
4. dry with materialdried over anhydrous sodium sulfate
5. customEvaporation of the solvent under reduced pressure