Hydrazine hydrate (1:1) → HCID 178468641, compound

HRID 915428Notes

Reaction equation

HRID 915428 reaction equation
[CH2:1]([O:3][C:4](=[O:21])/[C:5](/O)=[CH:6]/[C:7](=O)[C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]([F:18])([F:17])[F:16])=[CH:10][CH:9]=1)[CH3:2].O.[NH2:23][NH2:24]>C(O)C>[CH2:1]([O:3][C:4]([C:5]1[CH:6]=[C:7]([C:8]2[CH:13]=[CH:12][C:11]([O:14][C:15]([F:18])([F:17])[F:16])=[CH:10][CH:9]=2)[NH:24][N:23]=1)=[O:21])[CH3:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178473091HCID 178473091, compound

Product 1

HCID 178468641HCID 178468641, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In analogy to the procedure described for example 4 b], (Z)-2-hydroxy-4-oxo-4-(4-trifluoromethoxy-phenyl)-but-2-enoic acid ethyl ester was reacted with hydrazine monohydrate in ethanol under reflux conditions to give 5-(4-trifluoromethoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester as yellow crystals.

Sources & evidence

ORD record
ord-1ec76067a8b54fd0b00fc3a43c0c00f0
Source dataset
uspto-grants-2007_09
Patent number
US07265149B2

Reaction notes

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